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A logical model for metabolic networks with inhibition

Demolombe, Robert and Fariñas del Cerro, Luis and Obeid, Naji A logical model for metabolic networks with inhibition. (2013) In: International Conference on Bioinformatics and Computational Biology (BIOCOMP), 22 July 2013 - 25 July 2013 (Las Vegas, United States).

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Abstract

Metabolic networks formed by long sequences of biochemical reactions have been widely investigated to determine the catalytic role of genomes and how they interfere in the process. Many tumors have been reported to be the result of a pathology in the cell's pathway. Knowing that the complexity of the imbrication of such networks is beyond human reasoning, the use of artificial intelligence to help scientists in their experiments might seem adapted. This paper aims to present a logical model for metabolic pathways capable of describing both positive and negative reactions (activations and inhibitions) based on a fragment of first order logic. We also present an efficient automated deduction method allowing us to predict results by deduction and infer reactions and proteins states by abductive reasoning

Item Type:Conference or Workshop Item (Paper)
Additional Information:Proceedings of the International Conference on Bioinformatics and Computational Biology" (BIOCOMP'13) ISBN:1-60132-234-8
Audience (conference):International conference proceedings
Uncontrolled Keywords:
Institution:Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Université de Toulouse > Université Toulouse - Jean Jaurès - UT2J (FRANCE)
Université de Toulouse > Université Toulouse 1 Capitole - UT1 (FRANCE)
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Deposited On:03 Jun 2015 13:22

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