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Segmentation of Dynamic PET Images with Kinetic Spectral Clustering

Mouysset, Sandrine and Zbib, Hiba and Stute, Simon and Girault, Jean-Marc and Charara, Jamal and Noailles, Joseph and Chalon, Sylvie and Buvat, Irène and Tauber, Clovis Segmentation of Dynamic PET Images with Kinetic Spectral Clustering. (2013) Physics in Medicine and Biology, 58 (19). 6931-6944. ISSN 0031-9155

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Official URL: http://dx.doi.org/10.1088/0031-9155/58/19/6931


Segmentation is often required for the analysis of dynamic positron emission tomography (PET) images. However, noise and low spatial resolution make it a difficult task and several supervised and unsupervised methods have been proposed in the literature to perform the segmentation based on semi-automatic clustering of the time activity curves of voxels. In this paper we propose a new method based on spectral clustering that does not require any prior information on the shape of clusters in the space in which they are identified. In our approach, the p-dimensional data, where p is the number of time frames, is first mapped into a high dimensional space and then clustering is performed in a low-dimensional space of the Laplacian matrix. An estimation of the bounds for the scale parameter involved in the spectral clustering is derived. The method is assessed using dynamic brain PET images simulated with GATE and results on real images are presented. We demonstrate the usefulness of the method and its superior performance over three other clustering methods from the literature. The proposed approach appears as a promising pre-processing tool before parametric map calculation or ROI-based quantification tasks.

Item Type:Article
Additional Information:Thanks to IOP Publishing editor. The definitive version is available at http://iopscience.iop.org/0031-9155/58/19/6931
HAL Id:hal-01130660
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Commissariat à l'Energie Atomique et aux énergies alternatives - CEA (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Other partners > Université de Paris Diderot - Paris 7 (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Université de Toulouse > Université Toulouse - Jean Jaurès - UT2J (FRANCE)
Université de Toulouse > Université Toulouse 1 Capitole - UT1 (FRANCE)
Other partners > Centre Hospitalier Régional Universitaire de Tours - CHU Tours (FRANCE)
Other partners > Université de Tours (FRANCE)
Other partners > Université Paris-Sud 11 (FRANCE)
Laboratory name:
FP7/2007-2013 - HEALTH-F2- 2011-278850
Deposited On:12 Mar 2015 10:10

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