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Controlled adsorption and release onto calcium phosphates materials and drug delivery applications

Barroug, Allal and Noukrati, Hassan and Errassifi, Farid and Sarda, Stéphanie and Cazalbou, Sophie and Combes, Christèle and Rey, Christian and Glimcher, Melvin J. Controlled adsorption and release onto calcium phosphates materials and drug delivery applications. (2013) MATEC Web of Conferences, 5. 03002-1. ISSN 2261-236X

(Document in English)

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Official URL: http://dx.doi.org/10.1051/matecconf/20130503002


The adsorptive properties of synthetic calcium phosphates analogous to bone mineral were examined with respect to cisplatin and risedronate, two biological active drugs; the uptake and release experiments were carried out under various conditions in order to understand the basic mechanism of interaction. The effect of temperature and solution composition were highlighted and discussed. The adsorption results obtained for the therapeutic agents demonstrated that, depending on the conditions investigated (nature of the sorbent, concentration range, ionic composition, temperature. . . ), the shape of the isotherms is of Freundlich or Langmuir type. The adsorption is described as an ion-exchange process in dilute solutions, while the interaction appears to be reactive for concentrated solutions (dissolution of mineral ions from the apatite substrate and formation of soluble calcium complex and/or precipitation of calcium salts involving sorbate molecules). The information gained on the surface reactivity of calcium phosphate were exploited to associate an antibiotic to calcium phosphate cements for drug delivery applications. The specimens were obtained by combination of calcium phosphate and calcium carbonate powders upon mixing with water. The physicochemical properties of the paste were altered by the drug loading method (in the liquid or solid phase). Thus, a dose-dependent effect was noticed for the paste setting time, hardening and the release process.

Item Type:Article
Additional Information:REMCES XII – XIIe Rencontre Marocaine sur la Chimie de l'État Solide (Casablanca, Maroc, 21-23 novembre 2012 ). Thanks to EDP Sciences. The definitive version is available at http://www.matec-conferences.org The original PDF of the article can be found at MATEC Web of Conferences website : http://www.matec-conferences.org/articles/matecconf/abs/2013/03/matecconf_remces12_03002/matecconf_remces12_03002.html
HAL Id:hal-01092611
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > University of Cadi Ayyad - UCAM (MOROCCO)
Other partners > Boston Children's Hospital (USA)
Laboratory name:
Deposited On:16 Oct 2014 14:55

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