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Synthesis and Characterization of Hydroxyapatite Ceramics Organofunctionalized with ATP (Adenosine Triphosphate)

Hammami, Khaled and Elloumi, Jihene and Aifa, Sami and Drouet, Christophe and El Feki, Hafed Synthesis and Characterization of Hydroxyapatite Ceramics Organofunctionalized with ATP (Adenosine Triphosphate). (2014) Journal of Advances in Chemistry, 9 (1). 1787-1797. ISSN 2321-807X

(Document in English)

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Official URL: https://doi.org/10.24297/jac.v9i1.2304


Adenosine triphosphate (ATP) is the main source of energy for cells. In this article we investigated, with a possible future finality in bone tissue engineering, the original association of ATP molecules and hydroxyapatite (HAp) fine powders. We have in particular inspected, in a preliminary way, the effects of the presence of ATP molecules on the physico-chemistry of apatite compounds obtained via co-precipitation. Hybrids were produced by association of increasing amounts of adenosine 5’-triphosphate (ATP) disodium hydrate salt with hydroxyapatite, leading to so-called “organoapatites”. The structure and composition of the polycrystalline hybrid compounds obtained were studied by XRD, FTIR, SEM and magic angle spinning (MAS) NMR techniques. The presence of ATP was found to alter the apatite crystallization process, leading to a departure from stoichiometry. MAS-NMR data attest to the presence of strong interactions between functional groups of ATP and apatite particles unveiling the obtainment of class II hybrids with potential future applications in cell-loaded bone scaffolds.

Item Type:Article
Additional Information:Thanks to the Council For Innovative Research. The definitive version is available at http://cirworld.org The original PDF of the article can be found at Journal of Advances in Chemistry website : http://cirjac.com/ojs/index.php/jac/article/view/4145
HAL Id:hal-01092592
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Université de Sfax (TUNISIA)
Laboratory name:
Deposited On:15 Oct 2014 13:18

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