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Composition and properties of silver-containing calcium carbonate–calcium phosphate bone cement

Jacquart, Sylvaine and Siadous, Robin and Hénocq-Pigasse, Christel and Bareille, Reine and Roques, Christine and Rey, Christian and Combes, Christèle Composition and properties of silver-containing calcium carbonate–calcium phosphate bone cement. (2013) Journal of Materials Science: Materials in Medicine, 24 (12). 2665-2675. ISSN 0957-4530

(Document in English)

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Official URL: http://dx.doi.org/10.1007/s10856-013-5014-2


The introduction of silver, either in the liquid phase (as silver nitrate solution: Ag(L)) or in the solid phase (as silver phosphate salt: Ag(S)) of calcium carbonate–calcium phosphate (CaCO3–CaP) bone cement, its influence on the composition of the set cement (C-Ag(L)and C-Ag(S) cements with a Ca/Ag atomic ratio equal to 10.3) and its biological properties were investigated. The fine characterisation of the chemical setting of silver-doped and reference cements was performed using FTIR spectroscopy. We showed that the formation of apatite was enhanced from the first hours of maturation of C-Ag(L) cement in comparison with the reference cement, whereas a longer period of maturation (about 10 h) was required to observe this increase for C-Ag(S) cement, although in both cases, silver was present in the set cements mainly as silver phosphate. The role of silver nitrate on the setting chemical reaction is discussed and a chemical scheme is proposed. Antibacterial activity tests (S. aureus and S. epidermidis) and in vitro cytotoxicity tests (human bone marrow stromal cells (HBMSC)) showed that silver-loaded CaCO3–CaP cements had antibacterial properties (anti-adhesion and anti-biofilm formation) without a toxic effect on HBMSC cells, making C-Ag(S) cement a promising candidate for the prevention of bone implant-associated infections.

Item Type:Article
Additional Information:Thanks to Springer Verlag. The definitive version is available at http://link.springer.com The original PDF of the article can be found at : http://link.springer.com/article/10.1007%2Fs10856-013-5014-2
HAL Id:hal-01153078
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UT3 (FRANCE)
Other partners > Université de Bordeaux 2 - Victor Segalen (FRANCE)
Laboratory name:
Agence Nationale de la Recherche (ANR)
Deposited On:14 Oct 2014 10:05

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