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Taxonomy and chemical characterization of new antibiotics produced by Saccharothrix SA198 isolated from a Saharan soil

Boubetra, Dalila and Sabaou, Nasserdine and Zitouni, Abdelghani and Bijani, Christian and Lebrihi, Ahmed and Mathieu, Florence Taxonomy and chemical characterization of new antibiotics produced by Saccharothrix SA198 isolated from a Saharan soil. (2013) Microbiological Research, vol. 168 (n° 4). pp. 223-230. ISSN 0944-5013

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Official URL: http://dx.doi.org/10.1016/j.micres.2012.11.005

Abstract

Actinomycete strain SA198, isolated from a Saharan soil sample of Algeria, exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, and phytopathogenic and toxinogenic fungi. The morphological and chemotaxonomic characteristics of the strain were consistent with those of the genus Saccharothrix. Analysis of the 16S rRNA gene sequence of strain SA198 showed a similarity level ranging between 97.2 and 98.8% within Saccharothrix species, S. australiensis being the most closely related. Two new active products were isolated by reverse HPLC using a C18 column. The ultraviolet–visible (UV–VIS), infrared (IR), mass, and 1Hand 14C nuclear magnetic resonance (NMR) spectra showed that these products were new bioactive compounds. The minimum inhibitory concentrations of these antibiotics showed a strong activity against fungi and moderate activities against Gram-positive and Gram-negative bacteria.

Item Type:Article
Additional Information:Thanks to Elsevier edition. The original publication is available at http://www.sciencedirect.com
HAL Id:hal-00876662
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Other partners > Ecole normale supérieure de Kouba (ALGERIA)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS (FRANCE)
Other partners > Université Moulay Ismaïl de Meknès (MOROCCO)
Laboratory name:
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Deposited By: Vincent GERBAUD
Deposited On:25 Oct 2013 08:52

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