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Synthesis of primary amines by one-pot reductive amination of aldehydes

Ayedi, Mohamed Ali and Le Bigot, Yves and Ammar, Houcine and Abid, Souhir and El Gharbi, Rachid and Delmas, Michel Synthesis of primary amines by one-pot reductive amination of aldehydes. (2013) Synthetic Communications, vol. 43 (n° 6). pp. 2127-2133. ISSN 0039-7911

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Official URL: http://dx.doi.org/10.1080/00397911.2012.714830

Abstract

We report here a novel, one-pot, two-step reductive amination of aldehydes for the atom-economical synthesis of primary amines. The amination step has been carried out with hydroxylammonium chloride and does not require the use of a base. In the subsequent reduction step, a metal zinc/hydrochloride acid system has been used. This method is applicable to both aliphatic and aromatic aldehydes. The operational simplicity, the short reaction times, and the mild reaction conditions add to the value of this method as a practical alternative to the reductive amination of aldehydes. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file.

Item Type:Article
Additional Information:Thanks to Taylor & Francis editor. The definitive version is available at http://www.tandfonline.com The original PDF can be found at Synthetic Communications website: http://www.tandfonline.com/doi/abs/10.1080/00397911.2012.714830#.Ul4uElBHAow
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Université de Sfax (TUNISIA)
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Deposited By: Vincent GERBAUD
Deposited On:16 Oct 2013 06:43

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