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Synthesis, metal complexation and biological evaluation of a novel semi-rigid bifunctional chelating agent for 99mTc labelling

Le Gal, Julien and Michaud, Sandra and Gressier, Marie and Coulais, Yvon and Benoist, Eric Synthesis, metal complexation and biological evaluation of a novel semi-rigid bifunctional chelating agent for 99mTc labelling. (2006) Bioorganic & Medicinal Chemistry, vol. 1 (n° 9). pp. 2904-2909. ISSN 0968-0896

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Official URL: http://dx.doi.org/10.1016/j.bmc.2005.12.005

Abstract

A novel bifunctional chelating agent bearing an aromatic ring has been synthesised and characterised. This ligand formed well-defined oxorhenium complexes. The analogous 99mTcO-complex was obtained in an excellent yield with high radiochemical purity (>95%). The biodistribution of the 99mTo-complex after intravenous injection studied in normal rats showed that the activity was excreted mainly via renal-urinary pathway indicating its use for labelling peptides with 99mTc.

Item Type:Article
Additional Information:This publication is available on http://www.sciencedirect.com/science/journal/09680896
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
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Deposited By:Thomas Bonnecarere

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