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Ethylenediamine- and propylenediaminediacetic acid derivatives as ligands for the "fac-[M(CO)3]+" core (M = Re, 99mTc)

Allali, Mustapha and Cousinié, Sandra and Gressier, Marie and Tessier, Christian and Beauchamp, André L. and Coulais, Yvon and Dartiguenave, Michèle and Benoist, Eric Ethylenediamine- and propylenediaminediacetic acid derivatives as ligands for the "fac-[M(CO)3]+" core (M = Re, 99mTc). (2006) Inorganica Chimica Acta, vol. 3 (n° 7). pp. 2128-2134. ISSN 0020-1693

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Official URL: http://dx.doi.org/10.1016/j.ica.2006.02.023

Abstract

The reaction of Re(CO)5Cl with o- or p-N-(nitrophenyl)ethylenediaminediacetic acid (H2L1, H2L2) and o- or p-N-(nitrophenyl)propylenediaminediacetic acid (H2L3, H2L4) in methanol leads to the formation of stable anionic [Et3NH][Re(CO)3(L)]·H2O complexes 1-4. These compounds have been characterized by means of IR, mass spectrometry, elemental analysis, NMR and conductimetry, as well as X-ray crystallography for 2 and 3. The [Re(CO)3]+ moiety is coordinated via the nitrogen of the iminodiacetic acid unit and two oxygens of monodentate carboxylate groups. In each case, the nitro group of the aromatic ring remains uncoordinated. The analogous technetium-99m complexes 1' and 3' were also prepared quantitatively by the reaction of H2L1 and H2L3, respectively, with the fac-[99mTc(CO)3(H2O)3]+ precursor in ethanol. The corresponding Re and 99mTc compounds were shown to possess the same structure by means of HPLC studies. The high affinity of these ligands for the Tc(I) or Re(I) core, coupled with the easiness of their derivatization (by reduction of the nitro group in amino group), implies that the utilization of this ligand system to develop target-specific radiopharmaceuticals for diagnosis and therapy is promising.

Item Type:Article
Additional Information:This publication is available on http://www.sciencedirect.com/science/journal/00201693
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > Université de Montréal - UdeM (CANADA)
French research institutions > Centre National de la Recherche Scientifique - CNRS
Other partners > Université Ibn Tofail - Faculté des sciences de Kénitra (MOROCCO)
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Deposited By: Thomas Bonnecarere
Deposited On:08 Sep 2008 07:22

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