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Role of eosinophils in the regulation of H. contortus infection in sheep

Terefe, Getachew. Role of eosinophils in the regulation of H. contortus infection in sheep. PhD, Institut National Polytechnique de Toulouse, 2007

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Official URL: http://ethesis.inp-toulouse.fr/archive/00000565/

Abstract

Eosinophils are effector cells that are consistently recruited in both blood and infected tissues during helminth infections. Experimental studies in this thesis explore the role of eosinophils in the resistance to H. contortus infection in sheep. Our results from in vitro studies show that sheep eosinophils are capable of killing H. contortus infective larvae in the presence of immune or non-immune sera. Data from the series of experimental infections undertaken in the course of our studies indicate the following observations: (1) H. contortus infection causes Th2-biazed immune response, which is more pronounced in a resistant breed, (2) correlations between blood and tissue eosinophilia and parasitological parameters were time-dependent, positive two weeks and negative 30 days post-infection, (3) in the early primary infection, the involvement of eosinophils in parasite rejection appears minimal, as tissue recruitment is a relatively late phenomenon and (4) worm development and fecundity are reduced when infections occur in an environment where blood and tissue eosinophilia are high. These results collectively indicate that eosinophils definitely involve in the innate and acquired resistance to H. contortus infection in sheep, but their relative importance in the presence of other immune components, appears to depend on factors such as availability of complement and specific antibody systems, and duration and frequency of infection

Item Type:PhD Thesis
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Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
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Research Director:
Jacquiet, Philippe
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