OATAO - Open Archive Toulouse Archive Ouverte Open Access Week

Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein

Bertagnoli, Stéphane and Gelfi, Jacqueline and Le Gall, Ghislaine and Boilletot, Eric and Vautherot, Jean-François and Rasschaert, Denis and Laurent, Sylvie and Petit, Frédérique and Boucraut-Baralon, Corine and Milon, Alain Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein. (1996) Journal of virology, vol. 7 (n° 8). pp. 5061-5066. ISSN 0022-538X

[img]
Preview
(Document in English)

PDF ( Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
107kB

Official URL: http://jvi.asm.org/cgi/reprint/70/8/5061?ck=nck

Abstract

Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease. These recombinant viruses expressed the RHDV capsid protein (VP60). The recombinant protein, which is 60 kDa in size, was antigenic, as revealed by its reaction in immunoprecipitation with antibodies raised against RHDV. Both recombinant viruses induced high levels of RHDV- and myxoma virus-specific antibodies in rabbits after immunization. Inoculations by the intradermal route protected animals against virulent RHDV and myxoma virus challenges.

Item Type:Article
Additional Information:Thanks to American Society for Microbiology. The original PDF of the article can be found at Journal of virology website : http://jvi.asm.org
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Institut National de la Recherche Agronomique - INRA
Other partners > Centre National d'Etudes Vétérinaires et Alimentaires - CNEVA (FRANCE)
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT
Laboratory name:
Statistics:download
Deposited By: Mathieu Andro

Repository Staff Only: item control page