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Maternal milk contains antimicrobial factors that protect young rabbits from enteropathogenic Escherichia coli infection

Gallois, Mélanie and Gidenne, Thierry and Tasca, Christian and Caubet, Cécile and Coudert, Cécile and Milon, Alain and Boullier, Séverine Maternal milk contains antimicrobial factors that protect young rabbits from enteropathogenic Escherichia coli infection. (2007) Clinical and Vaccine Immunology, vol. 1 (n° 5). pp. 585-592. ISSN 1556-6811

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Official URL: http://cvi.asm.org/cgi/reprint/14/5/585

Abstract

Enteropathogenic Escherichia coli (EPEC) colibacillosis represents a major cause of lethal diarrhea in young children in developing countries. EPEC strains also infect numerous mammal species and represent a major economical problem in rabbit industry. Protection against this pathogen is a challenging goal both in humans and in other mammal species. Despite a good knowledge of the pathogenicity mechanisms of EPEC, the intrinsic and environmental factors that control the expression of EPEC virulence in mammals remain unknown. For instance, the exacerbated sensitivity of young mammals to EPEC infection is still unexplained. Our goal was to investigate if age or other factors, like milk consumption, could be determinants that trigger the disease. We used rabbits as an animal model to study the role of milk in the sensitivity to an EPEC infection. Weaned and suckling rabbits were orally inoculated with EPEC strain E22 (O103:H2:K-) at 28 days of age, and the evolution of the disease was investigated in the two groups. In addition, in order to better characterize the interactions between milk and EPEC, we determined in vitro bacterial growth and the abilities of EPEC cells to adhere to epithelial cells in the presence of milk. Our results demonstrate a protective role of milk in vivo in association with in vitro antibacterial activity. These effects are independent of the presence of specific anti-EPEC antibodies.

Item Type:Article
Additional Information:Thanks to American Society for Microbiology editor. The original PDF of the article can be found at Clinical and Vaccine Immunology website : http://cvi.asm.org
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Institut National de la Recherche Agronomique - INRA
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT
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Deposited By: Mathieu Andro
Deposited On:08 Sep 2008 08:20

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