OATAO - Open Archive Toulouse Archive Ouverte Open Access Week

Identification of a new strain of Actinomadura isolated from Saharan soil and partial characterization of its antifungal compounds

Badji, Boubekeur and Mostefaoui, Abdallah and Sabaou, Nasserdine and Mathieu, Florence and Lebrihi, Ahmed Identification of a new strain of Actinomadura isolated from Saharan soil and partial characterization of its antifungal compounds. (2011) African Journal of Biotechnology, vol. 10 (n° 63). pp. 13878-13886. ISSN 1684-5315

[img]
Preview
(Document in English)

PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
617kB

Official URL: http://dx.doi.org/10.5897/AJB11.999

Abstract

One promising strain Actinomadura sp. AC170, isolated from Algerian Saharan soil, with strong antifungal activity against pathogenic and toxinogenic fungi, was selected for further studies. The 16S rRNA results showed a distinct phylogenetic lineage from the other species within the Actinomadura genus. The production of antibiotic substances was investigated using GYEA solid medium. The butanolic extract contained four bioactive spots detected on thin layer chromatography plates. Among these antibiotics, a complex called 170A, which showed the more interesting antifungal activity, was selected and purified by reverse-phase HPLC. This complex is composed of four compounds. Ultraviolet-visible, infrared, mass and H nuclear magnetic resonance spectroscopy studies showed that these molecules contain an aromatic ring substituted by aliphatic chains. These compounds differ from the known antibiotics produced by Actinomadura species.

Item Type:Article
Additional Information:Thanks to Academic Journals editor. The definitive version is available at http://www.academicjournals.org The original PDF of the article can be found at : http://www.academicjournals.org/AJB/abstracts/abs2011/17Oct/Badji%20et%20al.htm
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Other partners > Ecole normale supérieure de Kouba (ALGERIA)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Laboratory name:
Statistics:download
Deposited By: Audrey LEFEVRE

Repository Staff Only: item control page