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Sonolysis of levodopa and paracetamol in aqueous solutions

Quesada-Peñate, Isariebel and Julcour-Lebigue, Carine and Jauregui-Haza, Ulises J. and Wilhelm, Anne-Marie and Delmas, Henri Sonolysis of levodopa and paracetamol in aqueous solutions. (2009) Ultrasonics Sonochemistry, vol. 16 (n° 5). pp. 610-616. ISSN 1350-4177

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Official URL: http://dx.doi.org/10.1016/J.ULTSONCH.2008.11.008

Abstract

Pharmaceutical products are often present in wastewater treatment effluents, rivers, lakes and, more rarely, in groundwater. The advanced oxidation methods, like ultrasound, find a promising future in the area of wastewater treatment. The aim of this paper is to evaluate the influence of several parameters of the ultrasound process on the degradation of paracetamol, a widely used non-steroidal anti-inflammatory recalcitrant drug found in water and levodopa, the most frequently prescribed drug for the treatment of Parkinson disease. Experiments were carried out at 574, 860 and 1134 kHz of ultrasonic frequency with horn-type sonicator and actual power values of 9, 17, 22 and 32 W at 20 °C. Initial concentrations of 25, 50, 100 and 150 mg L−1 of both products were used. Treatment efficiency was assessed following changes in pharmaceuticals concentration and chemical oxygen demand. The sonochemical degradation of both products follows a pseudo-first-order reaction kinetics. Complete removal of pharmaceuticals was achieved in some cases but some dissolved organic carbon remains in solution showing that long lived intermediates were recalcitrant to ultrasound irradiation. Pollutants conversion and COD removal were found to decrease with increasing the initial solute concentration and decreasing power. The best results were obtained with 574 kHz frequency. Investigations using 1-butanol as radical scavenger and H2O2 as promoter revealed that pollutants degradation proceeds principally through radical reactions, although some differences were observed between both molecules. Addition of H2O2 had a positive effect on degradation rate, but the optimum concentration of hydrogen peroxide depends on the pollutant.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at :http://www.sciencedirect.com/science/article/pii/S1350417708001855
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > Centro de Quimica Farmacéutica (CUBA)
Other partners > Instituto Superior de Tecnologias y Ciencias Aplicadas - InSTEC (CUBA)
Laboratory name:
Laboratoire de Génie Chimique - LGC (Toulouse, France) - Réaction, mélange & séparation (RMS)
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Deposited By: Audrey LEFEVRE

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