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Purification and structure elucidation of three naturally bioactive molecules from the new terrestrial Streptomyces sp. TN17 strain

Smaoui, Slim and Mellouli, Lofti and Lebrihi, Ahmed and Coppel, Yannick and Fourati Ben Fguira, Lilia and Mathieu, Florence Purification and structure elucidation of three naturally bioactive molecules from the new terrestrial Streptomyces sp. TN17 strain. (2011) Natural Product Research, vol. 25 (n° 8). pp. 806-814. ISSN 1478-6419

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Official URL: http://dx.doi.org/10.1080/14786410902986225

Abstract

Thirty litres of fermentation broth was extracted from the newly isolated Streptomyces sp. strain TN17 and various separation and purification steps led to the isolation of three pure bioactive compounds (1–3). Compound 1: cyclo (L-Leu-L-Arg), a diketopiperazine ‘DKP’ derivative; 2: di-(2-ethylhexyl) phthalate, a phthalate derivative; and 3: cyclo 1-[2-(cyclopentanecarbonyl-3-phenyl-propionyl]-pyrrolidine-2-carboxylic acid (1-carbamoyl-propyl)-amide, a cyclic tetrapeptide derivative. The chemical structure of these three active compounds was established on the basis of spectroscopic studies (MS and NMR) and by comparison with data from the literature. According to our biological studies, the pure compounds (1–3) possess antibacterial and antifungal activities.

Item Type:Article
Additional Information:Thanks to Taylor and Francis editor. The definitive version is available at http://www.tandfonline.com The original PDF of the article can be found at : http://www.tandfonline.com/doi/abs/10.1080/14786410902986225
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > Université de Sfax (TUNISIA)
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Deposited By:Audrey LEFEVRE

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