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Response to Comments of Peter G. Mantle

Schwartz, Gary G. and Manderville, Richard A. and Pfohl-Leszkowicz, Annie Response to Comments of Peter G. Mantle. (2010) Toxins, vol. 2 (n° 10). pp. 2337-2339. ISSN 2072-6651

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Official URL: http://dx.doi.org/10.3390/TOXINS2102337

Abstract

The apparently high yield of testis tumors (25%) in rats exposed long-term to Ochratoxin A (OTA) is uninterpretable without data on tumor yield in unexposed rats. Conversely, our demonstration that prenatal exposure to OTA induces DNA adducts in the testes of newborn mice and the absence of these adducts in the testes of mice not exposed prenatally to OTA, is evidence for the presumptive carcinogenicity of OTA in the testis. Together with recent data showing that prenatal exposure to OTA depresses expression of DMRT1, a tumor suppressor gene in the testis, our findings suggest that OTA may be a cause of testicular cancer.

Item Type:Article
Additional Information:Thanks to MDPI editor. The definitive version is available at http://www.mdpi.com The original PDF of the article can be found at : http://www.mdpi.com/2072-6651/2/10/2337/htm
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > University of Guelph (CANADA)
Other partners > Wake Forest University (USA)
Laboratory name:
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Deposited By: Audrey LEFEVRE
Deposited On:31 May 2012 07:54

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