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Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test

Khadra, Ahmed and Pinelli, Eric and Lacroix, M.Z. and Bousquet-Mélou, Alain and Hamdi, Hassan and Merlina, Georges and Guiresse, Maritxu and Hafidi, Mohamed Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test. (2012) Ecotoxicology and Environmental Safety, vol. 76 . pp. 187-192. ISSN 0147-6513

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Official URL: http://dx.doi.org/10.1016/j.ecoenv.2011.10.012

Abstract

The genotoxicity of quinolone and fluroquinolones was assessed using the micronucleus (MN) test on Viciafaba roots by direct contact exposure to a solid matrix. Plants were exposed to quinolones (nalidixic acid) and fluoroquinolones (ciprofloxacin and enrofloxacin) alone or mixed with artificially contaminatedsoils. Four different concentrations of each of these antibiotics were tested (0.01, 0.1, 1 and 10 mg/Kg) for nalidixic acid and (0.005, 0.05, 0.5 and 5 mg/Kg) for ciprofloxacin and enrofloxacin. These antibiotics were also used in mixture. Exposure of Vicia faba plants to each antibiotic at the highest two concentrations showed significant MN induction. The lowest two concentrations had no significant genotoxic effect. The mixture of the three compounds induced a significant MN induction whatever the mixture tested, from 0.02 to 20 mg/Kg. The results indicated that a similar genotoxic effect was obtained with the mixture at 0.2 mg/Kg in comparison with each molecule alone at 5–10 mg/Kg. Data revealed a clear synergism of these molecules on Vicia faba genotoxicity.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT
Université de Toulouse > Ecole d'Ingénieurs de Purpan
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
French research institutions > Institut National de la Recherche Agronomique - INRA
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > University of Cadi Ayyad - UCAM (MOROCCO)
Laboratory name:
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Deposited By: Nadia Kelmouss
Deposited On:31 May 2012 09:31

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