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Use of percolation ptThreshold as element of preformulation of orthopaedic cements used as drug delivery systems

Cazalbou, Sophie and Cavalie, Sandrine and Brouillet, Fabien and Tourrette, Audrey and Rodriguez, Fernand Use of percolation ptThreshold as element of preformulation of orthopaedic cements used as drug delivery systems. (2011) Journal of the Australian Ceramics Society , vol. 47 (n° 2). pp. 13-15. ISSN 0004-881X

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Official URL: http://www.austceram.com/ACS-Journal-2011-v2-3.htm

Abstract

The theory of the percolation has been proposed to solve the following problem: "What is the probability that the center of a porous material immersed in a fluid is wet?" This theory used in biomaterial domain permit to determine the percolation threshold of orthopaedic cement associated with porogenic agent containing drug. Porogenic agent containing Ibuprofen is introduced into phosphocalcic cement in order to ensure a sustained release as well as an interconnecting porosity. The granulometry and rate of introduced active agent are modified in order to study the influence of such parameters on the kinetic release. The knowledge of the percolation threshold of this "drug delivery system" permits to establish the link between dissolution profile of the drug, porous network and characteristics of the system. It can be used as element of pre-formulation and make it possible to predict the behaviour of the drug delivery system according to the characteristics of component constituting the system.

Item Type:Article
Additional Information:L'editeur ne permet pas la diffusion en archive ouverte. Open access is not allowed for this article.
Audience (journal):International peer-reviewed journal
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Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
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Deposited By: Denis Faragou
Deposited On:26 Nov 2012 17:29

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