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In vitro Assessment of the Pulmonary Toxicity and Gastric Availability of Lead-Rich Particles from a Lead Recycling Plant

Uzu, Gaëlle and Sauvain, Jean-Jacques and Baeza-Squiban, Armelle and Riediker, Michael and Hohl, Sandoval and Sanchez Sandoval Hohl, Magdalena and Val, Stéphanie and Tack, Karine and Denys, Sébastien and Pradère, Philippe and Dumat, Camille In vitro Assessment of the Pulmonary Toxicity and Gastric Availability of Lead-Rich Particles from a Lead Recycling Plant. (2011) Environmental Science & Technology, vol. 45 (n° 18). pp. 7888-7895. ISSN 0013-936X

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Official URL: http://dx.doi.org/10.1021/es200374c

Abstract

Epidemiological studies in urban areas have linked increasing respiratory and cardiovascular pathologies with atmospheric particulate matter (PM) from anthropic activities. However, the biological fate of metal-rich PM industrial emissions in urban areas of developed countries remains understudied. Lead toxicity and bioaccessibility assessments were therefore performed on emissions from a lead recycling plant, using complementary chemical acellular tests and toxicological assays, as a function ofPM size (PM10-2.5, PM2.5-1 and PM1) and origin (furnace, refining and channeled emissions). Process PM displayed differences in metal content, granulometry, and percentage of inhalable fraction as a function of their origin. Lead gastric bioaccessibility was relatively low (maximum 25%) versus previous studies; although, because of high total lead concentrations, significant metal quantities were solubilized in simulated gastrointestinal fluids. Regardless of origin, the finest PM1 particles induced the most significant pro-inflammatory response in human bronchial epithelial cells. Moreover, this biological response correlated with prooxidant potential assay results, suggesting some biological predictive value for acellular tests. Pulmonary effects from lead-rich PM could be driven by thiol complexation with either lead ions or directly on the particulate surface. Finally, health concern of PM was discussed on the basis of pro-inflammatory effects, accellular test results, and PM size distribution.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
French research institutions > Institut National de l'Environnement Industriel et des Risques - INERIS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
French research institutions > Institut de Recherche pour le Développement - IRD
Other partners > Institute for Work and Health (SWITZERLAND)
Other partners > Université de Paris Diderot - Paris 7 (FRANCE)
Other partners > Société de Traitement Chimique des Métaux - STCM (FRANCE)
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Laboratory name:
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Deposited By: Nadia Kelmouss
Deposited On:03 May 2012 13:49

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