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Analysis of the molecular mobility of collagen and elastin in safe, atheromatous and aneurysmal aortas

Samouillan, Valérie and Dandurand, Jany and Lacabanne, Colette and Stella, Andréa and Gargiulo, Mauro and Degani, Annamaria and Gandaglia, Alessandro and Spina, Michel Analysis of the molecular mobility of collagen and elastin in safe, atheromatous and aneurysmal aortas. (2012) Pathologie Biologie, vol. 60 (n° 1). pp. 58-65. ISSN 0369-8114

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Official URL: http://dx.doi.org/10.1016/j.patbio.2011.11.006

Abstract

Aim of the study In this study, we propose to use a thermal technique, Differential Scanning Calorimetry (DSC) to follow the evolution of elastin and collagen in safe and pathological cardiovascular tissues. Patients and methods The first part of this study deals with the analysis of the elastin network and associated proteins during ageing (from children to old persons) in aortic walls. The second part is devoted to the characterization of the collagenic phase in aneurysms. In both cases, physical data are correlated with biochemical analyses. Results and conclusion For old persons aortas with atheromatous stades, elastin and associated proteins are found to interpenetrate to form a homogenous phase. Abdominal aortic aneurysms (AAA) are characterized by structural alterations of the aortic wall resulting from the degradation of elastic fibers and an increase of collagen/elastin ratio. Notable modifications are evidenced between collagen from control tissue and collagen from AAA, particularly concerning the thermal denaturation. Biochemical and thermal results are compatible with the increase of new collagen deposition and/or impairment of the collagen phase stability in the extracellular matrix of AAAs.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The original version is available at http://www.sciencedirect.com The original PDF of the article can be found at http://www.sciencedirect.com.chimie.gate.inist.fr/science/article/pii/S0369811411001714
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > Policlinico S. Orsola-Malpighi (ITALY)
Other partners > Università degli Studi di Padova (ITALY)
Laboratory name:
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Deposited By: Denis Faragou

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