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From homogeneous to fractal normal and tumorous microvascular networks in the brain

Risser, Laurent and Plouraboué, Franck and Steyer, Alexandre and Cloetens, Peter and Le Duc, Géraldine and Fonta, Caroline From homogeneous to fractal normal and tumorous microvascular networks in the brain. (2006) Journal of Cerebral Blood Flow and Metabolism, vol. 27 (n° 2). pp. 293-303. ISSN 0271-678X

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Official URL: http://dx.doi.org/10.1038/sj.jcbfm.9600332

Abstract

We studied normal and tumorous three-dimensional (3D) microvascular networks in primate and rat brain. Tissues were prepared following a new preparation technique intended for high-resolution synchrotron tomography of microvascular networks. The resulting 3D images with a spatial resolution of less than the minimum capillary diameter permit a complete description of the entire vascular network for volumes as large as tens of cubic millimeters. The structural properties of the vascular networks were investigated by several multiscale methods such as fractal and power- spectrum analysis. These investigations gave a new coherent picture of normal and pathological complex vascular structures. They showed that normal cortical vascular networks have scale- invariant fractal properties on a small scale from 1.4 lm up to 40 to 65 lm. Above this threshold, vascular networks can be considered as homogeneous. Tumor vascular networks show similar characteristics, but the validity range of the fractal regime extend to much larger spatial dimensions. These 3D results shed new light on previous two dimensional analyses giving for the first time a direct measurement of vascular modules associated with vessel-tissue surface exchange.

Item Type:Article
Additional Information:Thanks to Nature Publishing group. This article is available at http://www.nature.com/jcbfm/index.html
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
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Deposited By: Franck PLOURABOUE

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