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Cerebral blood flow modeling in primate cortex

Guibert, Romain and Fonta, Caroline and Plouraboué, Franck Cerebral blood flow modeling in primate cortex. (2010) Journal of Cerebral Blood Flow & Metabolism, vol. 30 (n° 11). pp. 1860-1873. ISSN 0271-678X

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Official URL: http://dx.doi.org/10.1038/jcbfm.2010.105

Abstract

We report new results on blood flow modeling over large volumes of cortical gray matter of primate brain. We propose a network method for computing the blood flow, which handles realistic boundary conditions, complex vessel shapes, and complex nonlinear blood rheology. From a detailed comparison of the available models for the blood flow rheology and the phase separation effect, we are able to derive important new results on the impact of network structure on blood pressure, hematocrit, and flow distributions. Our findings show that the network geometry (vessel shapes and diameters), the boundary conditions associated with the arterial inputs and venous outputs, and the effective viscosity of the blood are essential components in the flow distribution. In contrast, we show that the phase separation effect has a minor function in the global microvascular hemodynamic behavior. The behavior of the pressure, hematocrit, and blood flow distributions within the network are described through the depth of the primate cerebral cortex and are discussed.

Item Type:Article
Additional Information:Thanks to Nature Publishing Group. The definitive version is available at http://www.nature.com. The original PDF of the article can be found at Journal of Cerebral Blood Flow & Metabolism website : http://www.nature.com/jcbfm/journal/v30/n11/full/jcbfm2010105a.html
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
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Deposited By:Franck PLOURABOUE

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