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A 3D-investigation shows that angiogenesis in primate cerebral cortex mainly occurs at capillary level

Risser, Laurent and Plouraboué, Franck and Cloetens, Peter and Fonta, Caroline A 3D-investigation shows that angiogenesis in primate cerebral cortex mainly occurs at capillary level. (2009) International Journal of Developmental Neuroscience, vol. 27 (n° 2). pp. 185-196. ISSN 0736-5748

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Official URL: http://dx.doi.org/10.1016/j.ijdevneu.2008.10.006

Abstract

This paper describes the use of a new 3D high-resolution imaging technique dedicated to functional vessels for a systematic quantitative study of angiogenesis in the primate cortex. We present a new method which permits, using synchrotron X-ray micro-tomography imaging, the identification of micro-vascular components as well as their automatic numerical digitalization and extraction from very large 3D image analysis and post-treatments. This method is used to analyze various levels of micro-vascular organization and their postnatal modifications. Comparing newborn- and adult marmosets, we found an increase in vascular volume (270%), exchange surface (260%) and vessel length (290%) associated to a decrease in distances between vessel and tissue (32%). The increase in relative vascular volumes between the two ages, examined through the whole cortical depth, has been found to be mainly sustained by events occurring at the capillary level, and only marginally at the perforating vessel level. This work shows that the postnatal cortical maturation classically described in terms of synaptogenesis, gliogenesis and connectivity plasticity is accompanied by an intensive remodeling of micro-vascular patterns.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com. The original PDF of the article can be found at International Journal of Developmental Neuroscience website : http://www.sciencedirect.com/science/journal/07365748
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Commissariat à l'Energie Atomique et aux énergies alternatives - CEA
French research institutions > Centre National de la Recherche Scientifique - CNRS
Other partners > European Synchrotron Radiation Facility - ESRF (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
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Deposited By:Franck PLOURABOUE

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