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Biomimetic nanocrystalline apatites: Emerging perspectives in cancer diagnosis and treatment

Al-Kattan, Ahmed and Girod Fullana, Sophie and Charvillat, Cédric and Ternet-Fontebasso, Hélène and Dufour, Pascal and Dexpert-Ghys, Jeannette and Santran, Véronique and Bordère, Julie and Pipy, Bernard and Bernad, José and Drouet, Christophe Biomimetic nanocrystalline apatites: Emerging perspectives in cancer diagnosis and treatment. (2012) International Journal of Pharmaceutics, vol. 423 (n° 1). pp. 26-36. ISSN 0378-5173

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Official URL: http://dx.doi.org/10.1016/j.ijpharm.2011.07.005

Abstract

Nanocrystalline calcium phosphate apatites constitute the mineral part of hard tissues, and the synthesis of biomimetic analogs is now wellmastered at the labscale. Recent advances in the fine physicochemical characterization of these phases enable one to envision original applications in the medical field along with a better understanding of the underlying chemistry and related pharmacological features. In this contribution, we specifically focused on applications of biomimetic apatites in the field of cancer diagnosis or treatment. We first report on the production and first biological evaluations (cytotoxicity, proinflammatory potential, internalization by ZR751 breast cancer cells) of individualized luminescent nanoparticles based on Eudoped apatites, eventually associated with folic acid, for medical imaging purposes. We then detail, in a first approach, the preparation of tridimensional constructs associating nanocrystalline apatite aqueous gels and drugloaded pectin microspheres. Sustained releases of a fluorescein analog (erythrosin) used as model molecule were obtained over 7 days, in comparison with the ceramic or microsphere reference compounds. Such systems could constitute original bonefilling materials for in situ delivery of anticancer drugs

Item Type:Article
Additional Information:Thanks to Elsevier editor. The original version is available at http://www.sciencedirect.com The original PDF of the article can be found at: http://www.sciencedirect.com/science/article/pii/S037851731100634X
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Other partners > ICELLTIS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM
French research institutions > Institut de Recherche pour le Développement - IRD
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
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Deposited By: Denis Faragou

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