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Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells

Volmer , Romain and Nazel-Sanchez, Beryl and Volmer, Christelle and Soubiès, Sébastien and Guérin, Jean-Luc Nucleolar localization of influenza A NS1: striking differences between mammalian and avian cells. (2010) Virology Journal, vol. 7 (63). pp.2-5. ISSN 1743-422X

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Official URL: http://dx.doi.org/10.1186/1743-422X-7-63

Abstract

In mammalian cells, nucleolar localization of influenza A NS1 requires the presence of a C-terminal nucleolar localization signal. This nucleolar localization signal is present only in certain strains of influenza A viruses. Therefore, only certain NS1 accumulate in the nucleolus of mammalian cells. In contrast, we show that all NS1 tested in this study accumulated in the nucleolus of avian cells even in the absence of the above described C-terminal nucleolar localization signal. Thus, nucleolar localization of NS1 in avian cells appears to rely on a different nucleolar localization signal that is more conserved among influenza virus strains.

Item Type:Article
Additional Information:Thanks to BioMed Central editor. The original PDF of the article can be found at : http://dx.doi.org/10.1186/1743-422X-7-63
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT
French research institutions > Institut National de la Recherche Agronomique - INRA
Other partners > University of St Andrews (UNITED KINGDOM)
Laboratory name:
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Deposited By:SYLVIE OUDDANE

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