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Carbon nanotube ecotoxicity in amphibians: assessment of ultiwalled carbon nanotubes and comparison with double-walled carbon nanotubes

Mouchet, Florence and Landois, Perine and Puech, Pascal and Pinelli, Eric and Flahaut, Emmanuel and Gauthier, Laury Carbon nanotube ecotoxicity in amphibians: assessment of ultiwalled carbon nanotubes and comparison with double-walled carbon nanotubes. (2010) Nanomedicine -Future Medicine, vol. 5 (n° 6). pp. 963-974. ISSN 1743-5889

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Official URL: http://dx.doi.org/10.2217/nnm.10.60

Abstract

The potential impact of industrial multiwalled carbon nanotubes (MWNTs) was investigated under normalized laboratory conditions according to the International Standard micronucleus assay ISO 21427–1 for 12 days of half-static exposure to 0.1, 1, 10 and 50 mg/l of MWNTs in water. Three different end points were carried out for 12 days of exposure: mortality, growth inhibition and micronuclei induction in erythrocytes of the circulating blood of larvae. Raman spectroscopy analysis was used to study the presence of carbon nanotubes in the biological samples. Considering the high diversity of carbon nanotubes according to their different characteristics, MWNTs were analyzed in Xenopus larvae, comparatively to double-walled carbon nanotubes used in a previous study in similar conditions. Growth inhibition in larvae exposed to 50 mg/l of MWNTs was evidenced; however, no genetoxicity (micronucleus assay) was noticed, at any concentration. Carbon nanotube localization in the larvae leads to different possible hypothesis of mechanisms explaining toxicity in Xenopus.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
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Deposited By:Leila Abdelouhab

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