OATAO - Open Archive Toulouse Archive Ouverte Open Access Week

Uptake and release of double-walled carbon nanotubes by mammalian cells

Neves, Vera and Heister, Elena and Costa, Sara and Tîlmaciu, Carmen and Borowiak-Palen, Ewa and Giusca, Cristina E. and Flahaut, Emmanuel and Soula, Brigitte and Coley, Helen M. and McFadden, Johnjoe and Silva, S. Ravi P. Uptake and release of double-walled carbon nanotubes by mammalian cells. (2010) Advanced Functional Materials, vol. 20 (n° 19). pp. 3272-3279. ISSN 1616-301X

[img]
Preview
(Document in English)

PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
991kB

Official URL: http://dx.doi.org/10.1002/adfm.201000994

Abstract

Efforts to develop carbon nanotubes (CNTs) as nano-vehicles for precise and controlled drug and gene delivery, as well as markers for in vivo biomedical imaging, are currently hampered by uncertainties with regard to their cellular uptake, their fate in the body, and their safety. All of these processes are likely to be affected by the purity of CNT preparation, as well as the size and concentration of CNTs used, parameters that are often poorly controlled in biological experiments. It is demonstrated herein that under the experimental conditions of standard transfection methods, DWNTs are taken up by cultured cells but are then released after 24 h with no discernable stress response. The results support the potential therapeutic use of CNTs in many biomedical settings, such as cancer therapy.

Item Type:Article
Additional Information:Thanks to John Wiley & Sons editor. The definitive version is available at http://onlinelibrary.wiley.com/ The original PDF of the article can be found at Advanced Functional Materials website : http://eu.wiley.com/WileyCDA/WileyTitle/productCd-2126.html
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Other partners > Szczecin University of Technology (POLAND)
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > University of Surrey (UNITED KINGDOM)
Laboratory name:
Statistics:download
Deposited By: Leila Abdelouhab
Deposited On:21 Jun 2011 08:46

Repository Staff Only: item control page