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Characterization of aneurysmal aortas by biochemical, thermal, and dielectric techniques

Samouillan, Valérie and Dandurand, Jany and Lacabanne, Colette and Stella, Andréa and Gargiulo, Mauro and Degani, Annamaria and Gandaglia, Alessandro and Spina, Michel Characterization of aneurysmal aortas by biochemical, thermal, and dielectric techniques. (2010) Journal of Biomedical Materials Research Part A, vol. 95A (n° 2). pp. 611-619. ISSN 1549-3296

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Official URL: http://dx.doi.org/10.1002/jbm.a.32835

Abstract

Abdominal aortic aneurysms (AAA) are characterized by structural alterations of the aortic wall resulting from the degradation of elastic fibres and an increase of collagen/elastin ratio. In this study we investigated the chain dynamics of AAA tissues by two techniques generally used for the characterization of polymers, Differential scanning calorimetry (DSC) and thermally stimulated currents (TSC), and we correlated the obtained data with biochemical analyses. The thermal denaturation of collagen observed by DSC allowed us to evaluate the thermal stability of the triple helix domain: notable modifications were evidenced between collagen from control tissue and collagen from AAA, particularly concerning the thermal denaturation. The dielectric analysis of pathologic aortic walls by TSC revealed a relevant change of collagen mobility in AAA, with the occurrence of a specific mode of relaxation between −60 and −40°C. Biochemical, thermal, and dielectric results are compatible with increase of new collagen deposition and/or impairment of the collagen phase stability in the extracellular matrix of AAAs.

Item Type:Article
Additional Information:The definitive version is available at http://onlinelibrary.wiley.com/
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Other partners > Università di Bologna (ITALY)
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > University of Padova (ITALY)
Laboratory name:
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Deposited By: Leila Abdelouhab

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