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Medical potentialities of biomimetic apatites through adsorption, ionic substitution, and mineral/organic associations: three illustrative examples

Al-Kattan, Ahmed and Errassifi, F. and Sautereau, Anne-Marie and Sarda, Stéphanie and Dufour, Pascal and Barroug, Allal and Dos Santos, Isabelle and Combes, Christèle and Grossin, David and Rey, Christian and Drouet, Christophe Medical potentialities of biomimetic apatites through adsorption, ionic substitution, and mineral/organic associations: three illustrative examples. (2010) Advanced Engineering Materials, vol. 12 (n° 7). pp. 1438-1656. ISSN 1438-1656

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Official URL: http://dx.doi.org/10.1002/adem.200980084

Abstract

Biomimetic calcium phosphate apatites are particularly adapted to bio-medical applications due to their biocompatibility and high surface reactivity. In this contribution we report three selected examples dealing with mineral/organic interactions devoted to convey new functionalities to apatite materials, either in the form of dry bioceramics or of aqueous colloids. We first studied the adsorption of risedronate (bisphosphonate) molecules, which present potential therapeutic properties for the treatment of osteoporosis. We then addressed the preparation of luminescent Eu-doped apatites for exploring apatite/collagen interfaces through the FRET technique, in view of preparing "advanced" biocomposites exhibiting close spatial interaction between apatite crystals and collagen fibers. Finally, we showed the possibility to obtain nanometer-scaled apatite-based colloids, with particle size tailorable in the range 30-100 nm by controlling the agglomeration state of apatite nanocrystals by way of surface functionalization with a phospholipid moiety. This paper is aimed at illustrating some of the numerous potentialities of calcium phosphate apatites in the bio-medical field, allowing one to foresee perspectives lying well beyond bone-related applications.

Item Type:Article
Additional Information:The definitive version is available at http://onlinelibrary.wiley.com/doi/10.1002/adem.200980084/abstract
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > Université de Bordeaux 2 - Victor Segalen (FRANCE)
Other partners > University of Cadi Ayyad - UCAM (MOROCCO)
Laboratory name:
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Deposited By:Leila Abdelouhab

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