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Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses

Camus-Bouclainville, Christelle and Gretillat, Magalie and Py, Robert and Gelfi, Jacqueline and Guérin, Jean-Luc and Bertagnoli, Stéphane Genome Sequence of SG33 Strain and Recombination between Wild-Type and Vaccine Myxoma Viruses. (2011) Emerging Infectious Diseases, vol. 17 (n° 4). pp.633-638. ISSN 1080-6040

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Official URL: http://dx.doi.org/10.3201/eid1704.101146

Abstract

Myxomatosis in Europe is the result of the release of a South America strain of myxoma virus in 1952. Several attenuated strains with origins in South America or California have since been used as vaccines in the rabbit industry.We sequenced the genome of the SG33 myxoma virus vaccine strain and compared it with those of other myxoma virus strains. We show that SG33 genome carries a large deletion in its right end. Furthermore, our data strongly suggest that the virus isolate from which SG33 is derived results from an in vivo recombination between a wild-type South America (Lausanne) strain and a California MSDderived strain. These finndings raise questions about the use of insufficiently attenuated virus in vaccination.

Item Type:Article
Additional Information:Thanks to National Center for Infectious Diseases editor. The original PDF of the article can be found at website : http://www.cdc.gov/eid/content/17/4/633.htm
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT
French research institutions > Institut National de la Recherche Agronomique - INRA
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Deposited By: SYLVIE OUDDANE
Deposited On:08 Apr 2011 13:08

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