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Conclusions of the French Food Safety Agency on the toxicity of bisphenol A

Arnich, Nathalie and Canivenc-Lavier, Marie-Chantal and Kolf-Clauw, Martine and Coffigny, Hervé and Cravedi, Jean-Pierre and Grob, Konrad and Macherey, Anne-Christine and Masset, Dominique and Maximilien, Rémi and Narbonne, Jean-François and Nesslany, Fabrice and Stadler, Jeanne and Tulliez, Jacques Conclusions of the French Food Safety Agency on the toxicity of bisphenol A. (2011) International Journal of Hygiene and Environmental Health, vol. 214 (n° 3). pp. 271-275. ISSN 1438-4639

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Official URL: http://dx.doi.org/10.1016/j.ijheh.2010.12.002

Abstract

Since more than 10 years, risk assessment of bisphenol A (BPA) is debated at the international level. In 2008, the U.S. National Toxicology Program (NTP) expressed some concern for adverse effects, at current level of exposure to BPA, on developmental toxicity. In this context, the French Food Safety Agency (AFSSA) decided to review the toxicity data on BPA with a special focus on this endpoint at doses below 5mg/kg bw/day (the no observed adverse effect level set by different regulatory bodies). This paper summarizes the conclusions of a collective assessment conducted by an expert Working Group from AFSSA. Studies were classified into 3 groups: (i) finding no toxicity, (ii) reporting results not considered to be of concern and (iii) indicating warning signals. The term "warning signal" means that no formal conclusion can be drawn regarding the establishment of a health based guidance value but the study raises some questions about the toxicity of BPA at low doses. It was concluded that studies are needed to ascertain the significance for human health of these warning signals and to be able to propose new methodologies for assessing the risks associated with low doses of BPA and more generally of endocrine disruptors.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The original PDF of the article is available at http://bit.ly/pjG6dN.
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Agence Française de Sécurité Sanitaire des Aliments - AFSSA (FRANCE)
Other partners > Agence Française de Sécurité Sanitaire des Produits de Santé - AFSSPS (FRANCE)
French research institutions > Commissariat à l'Energie Atomique et aux énergies alternatives - CEA
French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT
French research institutions > Institut National de la Recherche Agronomique - INRA
Other partners > Institut Pasteur (FRANCE)
Other partners > Official Food Control Authority (SWITZERLAND)
Other partners > Université de Bourgogne - UB (FRANCE)
Other partners > Université de Bordeaux 1 (FRANCE)
Laboratory name:
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Deposited By: martine kolf-clauw
Deposited On:16 Feb 2011 14:54

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