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Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved

Bastide, Nadia and Pierre, Fabrice and Corpet, Denis E. Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved. (2011) Cancer Prevention Research, vol. 4 (n° 2). pp. 177-184. ISSN 1940-6207

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Official URL: http://dx.doi.org/10.1158/1940-6207.CAPR-10-0113

Abstract

Red meat and processed meat intake is associated with a risk of colorectal cancer, a major cause of death in affluent countries. Epidemiological and experimental evidence supports the hypothesis that heme iron present in meat promotes colorectal cancer. This meta-analysis of prospective cohort studies of colon cancer reporting heme intake included 566,607 individuals and 4,734 cases of colon cancer. The summary relative risk of colon cancer was 1.18 [95%C.I.: 1.06-1.32] for subjects in the highest category of heme iron intake compared with those in the lowest category. Epidemiological data thus show a suggestive association between dietary heme and risk of colon cancer. The analysis of experimental studies in rats with chemically-induced colon cancer showed that dietary hemoglobin and red meat consistently promote aberrant crypt foci, a putative pre-cancer lesion. The mechanism is not known, but heme iron has a catalytic effect on (i) the endogenous formation of carcinogenic N-nitroso compounds and (ii) the formation of cytotoxic and genotoxic aldehydes by lipoperoxidation. A review of evidence supporting these hypotheses suggests that both pathways are involved in heme iron toxicity

Item Type:Article
Additional Information:Thanks to the American Association for Cancer Research editor. The original PDF of the article is available on Cancer Prevention Research website : http://cancerpreventionresearch.aacrjournals.org/content/4/2/177
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT
French research institutions > Institut National de la Recherche Agronomique - INRA
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Deposited By:Denis CORPET

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