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Cyclophosphamide removal from water by nanofiltration and reverse osmosis membrane

Wang, Li and Albasi, Claire and Faucet-Marquis, Virginie and Pfohl-Leszkowicz, Annie and Dorandeu, Christophe and Marion, Bénédicte and Causserand, Christel Cyclophosphamide removal from water by nanofiltration and reverse osmosis membrane. (2009) Water Research, vol. 43 (n° 17). pp. 4115-4122. ISSN 0043-1354

(Document in English)

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Official URL: http://dx.doi.org/10.1016/j.watres.2009.06.007


The rejection of cyclophosphamide (CP) by nanofiltration (NF) and reverse osmosis (RO) membranes from ultrapure (Milli-Q) water and membrane bioreactor (MBR) effluent was investigated. Lyophilization–extraction and detection methods were first developed for CP analysis in different water matrices. Experimental results showed that the RO membrane provided excellent rejection (>90%) under all operating conditions. Conversely, efficiency of CP rejection by NF membrane was poor: in the range of 20–40% from Milli-Q water and around 60% from MBR effluent. Trans-membrane pressure, initial CP concentration and ionic strength of the feed solution had almost no effect on CP retention by NF. On the other hand, the water matrix proved to have a great influence: CP rejection rate by NF was clearly enhanced when MBR effluent was used as the background solution. Membrane fouling and interactions between the CP and water matrix appeared to contribute to the higher rejection of CP.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Water Research website : http://www.sciencedirect.com/science/journal/00431354
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > Université de Montpellier 1 (FRANCE)
Laboratory name:
Deposited By:Claire ALBASI

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