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Safety and efficacy of an inactivated Carbopol-adjuvanted goose haemorrhagic polyomavirus vaccine for domestic geese

Gelfi, Jacqueline and Pappalardo, Michaël and Claverys, Carine and Peralta, Brigitte and Guérin, Jean-Luc Safety and efficacy of an inactivated Carbopol-adjuvanted goose haemorrhagic polyomavirus vaccine for domestic geese. (2010) Avian Pathology, vol. 39 (n° 2). pp. 111-116. ISSN 0307-9457

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Official URL: http://dx.doi.org/10.1080/03079451003604647

Abstract

Haemorrhagic nephritis enteritis of the goose (HNEG) is an epizootic viral disease in domestic geese. The causal agent is a polyomavirus, namely goose haemorrhagic polyomavirus. To help control the disease, an inactivated vaccine was developed, based on viral particles produced in goose kidney cells. Viral material was quantified using real-time quantitative polymerase chain reaction, inactivated with b-propiolactone and adjuvanted with Carbopol, an acrylic acid polymer. Carbopol proved to be more immunogenic than aluminium hydroxide and was totally safe when administered to young goslings and breeders alike. Carbopol-adjuvanted vaccine induced a high serological response. Moreover, goslings hatched from vaccinated breeders were protected against viral challenge, indicating that maternally-derived neutralizing antibodies (MDA) were efficiently transferred. MDA were still detectable 15 days post-hatch. Clinical trials will be necessary to accurately evaluate a vaccine-based HNEG control strategy under field conditions.

Item Type:Article
Audience (journal):International peer-reviewed journal
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Institution: Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT
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Deposited By: Jean-Luc Guerin
Deposited On:20 May 2010 13:18

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