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New Advances in Nanocrystalline Apatite Colloids Intended for Cellular Drug Delivery

Bouladjine, Amal and Al-Kattan, Ahmed and Dufour, Pascal and Drouet, Christophe New Advances in Nanocrystalline Apatite Colloids Intended for Cellular Drug Delivery. (2009) Langmuir, vol.25 (20). pp. 12256-12265. ISSN 0743-7463

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Official URL: http://dx.doi.org/10.1021/la901671j

Abstract

Intracellular drug delivery using colloidal biomimetic calcium phosphate apatites as nanocarriers is a seducing concept. However, the colloid preparation to an industrial scale requires the use of easily handled raw materials as well as the possibility to tailor the nanoparticles size. In this work, the stabilization of the colloids was investigated with various biocompatible agents. Most interestingly, nanoscale colloids were obtained without the need for toxic and/or hazardous raw materials. Physico-chemical characteristics were investigated by chemical analyses, dynamic light scattering, FTIR/Raman spectroscopies, XRD, and electron microscopy. A particularly promising colloidal system associates biomimetic apatite stabilized with a natural phospholipid moiety (AEPr, 2-aminoethylphosphoric acid). Complementary data described such colloids as apatite nanocrystals covered with surface Ca2þ (AEPr-)2 complexes involving “supernumerary” Ca2þ ions. The effects of the concentration in AEPr, synthesis temperature, duration of aging in solution, pH, and sonication were followed, showing that it is possible to modulate the mean size of the nanoparticles, typically in the range 30-100 nm. The perfect biocompatibility of such colloids allied to the possibility to prepare them from innocuous compounds shows great promise for intracellular drug delivery.

Item Type:Article
Additional Information:Thanks to American Chemical Society editor. The definitive version is available at www.acs.org/ The original PDF of the article can be found at Langmuir website :http://pubs.acs.org/doi/abs/10.1021/la901671j
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
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Deposited By: Nihad Lahdifi

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