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Changes in the physical structure and chain dynamics of elastin network in homocysteine-cultured arteries

Samouillan, Valérie and Lamy, Edouard and Dandurand, Jany and Foucault-Bertaud, Alexandrine and Chareyre, Corinne and Lacabanne, Colette and Charpiot, Philippe Changes in the physical structure and chain dynamics of elastin network in homocysteine-cultured arteries. (2009) Journal of Biomedical Materials Research Part A, vol. 93A (n° 2). 696 -703. ISSN 1549-3296

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Official URL: http://dx.doi.org/10.1002/jbm.a.32570

Abstract

The thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries. The physical structure of this amorphous protein was investigated by differential scanning calorimetry (DSC). To explore the molecular dynamics of the elastin network in the nanometer range, we used thermally stimulated currents (TSC), a dielectric technique running at low frequency, and measuring the dipolar reorientations in proteins subjected to a static electrical field. Combining DSC and TSC experiments reveals the molecular mobility of the proteins, both in the glassy state and in the liquid state. Significant differences are evidenced in the physical structure and relaxation behavior of elastin network in cultured arteries (physiological and pathological concentrations of homocysteine) and discussed.

Item Type:Article
Additional Information:Thanks to John Wiley & Sons editor. The definitive version is available at http://eu.wiley.com/WileyCDA/Section/index.html The original PDF of the article can be found at Journal of Biomedical Materials Research Part Awebsite : http://www3.interscience.wiley.com/journal/122513514/abstract?CRETRY=1&SRETRY=0
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > Université de la Méditerranée - Aix-Marseille II (FRANCE)
Laboratory name:
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Deposited By: Nihad Lahdifi

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