Samouillan, Valérie and Lamy, Edouard and Dandurand, Jany and Foucault-Bertaud, Alexandrine and Chareyre, Corinne and Lacabanne, Colette and Charpiot, Philippe Influence of homocysteine on the physical structure and molecular mobility of elastin network in cultured arteries. (2009) Journal of Non-Crystalline Solids, vol. 3 (n° 14-). pp. 830-835. ISSN 0022-3093
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Official URL: http://dx.doi.org/10.1016/j.jnoncrysol.2009.04.027
The thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries. The glass transition of this amorphous protein was investigated by Differential Scanning Calorimetry (DSC). To explore the molecular dynamics of the elastin network in the nanometer range, we used Thermally Stimulated Currents (TSC), a dielectric technique running at low frequency and measuring the dipolar reorientations in proteins subjected to a static electrical field. Combining TSC and DSC experiments with determination of the activation parameters of relaxation times reveals the molecular mobility of the proteins. The major differences in the relaxation behavior of elastin between arteries cultured with physiological and pathological concentrations of homocysteine are discussed.
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