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Influence of homocysteine on the physical structure and molecular mobility of elastin network in cultured arteries

Samouillan, Valérie and Lamy, Edouard and Dandurand, Jany and Foucault-Bertaud, Alexandrine and Chareyre, Corinne and Lacabanne, Colette and Charpiot, Philippe Influence of homocysteine on the physical structure and molecular mobility of elastin network in cultured arteries. (2009) Journal of Non-Crystalline Solids, vol. 3 (n° 14-). pp. 830-835. ISSN 0022-3093

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Official URL: http://dx.doi.org/10.1016/j.jnoncrysol.2009.04.027

Abstract

The thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries. The glass transition of this amorphous protein was investigated by Differential Scanning Calorimetry (DSC). To explore the molecular dynamics of the elastin network in the nanometer range, we used Thermally Stimulated Currents (TSC), a dielectric technique running at low frequency and measuring the dipolar reorientations in proteins subjected to a static electrical field. Combining TSC and DSC experiments with determination of the activation parameters of relaxation times reveals the molecular mobility of the proteins. The major differences in the relaxation behavior of elastin between arteries cultured with physiological and pathological concentrations of homocysteine are discussed.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Journal of Non-Crystalline Solids website : http://www.sciencedirect.com/science/journal/00223093
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Université de la Méditerranée - Aix-Marseille II (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
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Deposited By: Nihad Lahdifi
Deposited On:18 May 2010 14:23

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