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Effect of cytostatic drugs on the sludge and on the mixed liquor characteristics of a cross-flow membrane bioreactor: Consequence on the process

Delgado, Luis Fernando and Faucet-Marquis, Virginie and Schetrite, Sylvie and Pfohl-Leszkowicz, Annie and Paranthoen, Sylvia and Albasi, Claire Effect of cytostatic drugs on the sludge and on the mixed liquor characteristics of a cross-flow membrane bioreactor: Consequence on the process. (2010) Journal of Membrane Science, 347 (1-2). pp. 165-173.

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Official URL: http://dx.doi.org/10.1016/j.memsci.2009.10.020

Abstract

The influence of cyclophosphamide and its principal metabolites (CPs) on the physicochemical properties of the mixed liquor of a cross-flow membrane bioreactor and the consequences for membrane fouling were investigated. The influence of CPs was determined by comparing the performance of two bioreactors running in parallel, MBR-CPs (with CPs) and MBR-control (without CPs). The physicochemical properties of the mixed liquor were characterized by soluble extracellular polymeric substances (soluble EPS content), particle size distribution and specific cake resistance. Results suggested that the CP toxicity altered the characteristics of the biological matrix of the activated sludge. Micro-organisms exposed to CPs showed higher endogenous respiration rates than MBR-control micro-organisms. The accumulation of soluble EPS and the formation of small particles (in MBR-CPs after cross-flow velocity was raised) increased the resistance to filtration. The fouling potential of the supernatant seemed to be linked more closely to the concentration of polysaccharides than of proteins and humic substances. Modifications of the membrane performance were observed. Under operating conditions, membrane fouling was faster in MBR-CPs than MBR-control. Moreover, the membrane played an important role in the permeate quality and the overall performance of the process, making possible the biological treatment of such an effluent

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:?? Pall_Exekia_Bazet ??
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
Laboratory name:
Laboratoire de Génie Chimique - LGC (Toulouse, France) - Bioprocédés et systèmes microbiens (BioSyM)
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Deposited By:Claire ALBASI

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