Corpet, Denis E. and Jacquinet, Claire and Peiffer, Ginette and Taché, Sylviane Insulin Injections Promote the Growth of Aberrant Crypt Foci in the Colon of Rats. (1997) Nutrition and Cancer .
|(Document in English) |
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The main objective of the present study was to test the hypothesis that exogenous insulin would enhance colon carcinogenesis. Thirty-six female F344 rats, fed ad libitum a low fat rodent chow, received a single azoxymethane injection (20 mg/kg), and were randomized a week later to two groups. Control rats were given 5 days a week a s.c. saline injection, and experimental rats were given ultralente bovine insulin, 20 U/kg. The promoting effect of insulin injections was assessed by the multiplicity (number of crypts) of aberrant crypt foci after 100 d of treatment (72 injections). The rats given insulin ate more and were heavier than controls (215 ± 11 vs. 182 ± 7 g, p<0.001). Insulin injections also increased the amount of abdominal fat, the plasma triglycerides, and the insulinemia, and decreased blood glucose (all p<0.05). The number of aberrant crypt foci was the same in both groups, but their multiplicity was significantly increased by the insulin injections (2.8 ± 0.3 vs. 2.5 ± 0.2 crypt/focus in controls, p=0.007). Besides, the proportion of sialomucin producing foci was higher in insulin injected rats than in controls (p=0.04). These data show that exogenous insulin can promote colon carcinogenesis in rats, and suggest that lifestyle and diets leading to low blood insulin might protect humans against colorectal cancer.
|Audience (journal):||International peer-reviewed journal|
|Institution:||French research institutions > Institut National de la Recherche Agronomique - INRA|
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT
Xénobiotiques (Toulouse, France) - Aliments & Cancers
|Total amount of citations (from ISI Web of Science):||82|
|Deposited By:||Denis CORPET|
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