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Exploration of the global antioxidant capacity of the stratum corneum by cyclic voltammetry

Casas-Cabanas, Montse and Comtat, Maurice and Gros, Pierre and Redoules, Daniel and Ruffien-Ciszak, Audrey and Schmitt, Anne-Marie and Questel, Emmanuel Exploration of the global antioxidant capacity of the stratum corneum by cyclic voltammetry. (2006) Journal of Pharmaceutical and Biomedical Analysis, vol. 40 (n° 1). pp. 162-167. ISSN 0731-7085

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Official URL: http://dx.doi.org/10.1016/j.jpba.2005.05.035

Abstract

Cyclic voltammetry is proposed as a new method for evaluating the antioxidant capacity of skin based on the reducing properties of low molecular weight antioxidants (LMWA). Experiments were performed simply by recording the anodic current at 0.9 V/SCE of a platinum microelectrode placed directly on the epidermis surface without any gel or water. This method ensured a direct, rapid (less than 1 min), reliable (accuracy 12%) and non-invasive measurement of the global antioxidant capacity of the stratum corneum with a high spatiotemporal resolution. At the same time, the pH of the skin surface was determined by recording the cathodic current at 0 V/SCE. Based on an exploratory study involving nine volunteer subjects, the evolution of the amperometric response of the microelectrode with time revealed a periodic modification of the redox properties.

Item Type:Article
Additional Information:This article is available at http://www.sciencedirect.com/science/article/pii/S0731708505004401
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Laboratoires Pierre Fabre (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
Laboratory name:
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Deposited By:Guylène Abadie

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