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Friedel-crafts acylation in supercritical CO2

Aribert, Nicolas and Camy, Séverine and Cognet, Patrick and Condoret, Jean-Stéphane and Lucchese, Yolande Friedel-crafts acylation in supercritical CO2. (2009) In: 2nd International Congress on Green Process Engineering,2nd European Process Intensification Conference, 14-17 June 2009, Venise,Italie .

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Abstract

Friedel-Crafts acylation is among the most fundamental and useful reactions to yield aromatic ketones but it is one of the less acceptable in terms of unwanted polluting by-products or atom economy because of overconsumption of conventional catalyst used in stoichiometric quantities. This route is nevertheless still widely used in the fine chemicals industry. In recent years, awareness of the impact of industrial activities on the environment has lead chemists to work on new chemical routes, less dangerous and more environmentally friendly. We considered here the acylation of benzofurane derivative by an acid chloride. In this study, one of the first solutions was to replace conventional catalysts by reusable solid catalysts. Indeed, a wide variety of new solid catalysts, more efficient and less polluting, has now emerged (zeolites, ion-exchange resins…). These catalysts were first tested in “conventional” conditions, i.e., using an organic solvent (dichlorobenzene in our case), to determine the best one, in terms of reactivity, lifetime and reusability (regeneration). The zeolite Y was found the most appropriate. However, the use of an organic solvent remaining questionable, we have also considered the use of supercritical carbon dioxide as the solvent. Its inherent properties include non-flammability, mild critical conditions, tuneable solubility near to the critical point and very low environmental impact. The reaction was then operated using a continuous high pressure fixed bed and results concerning yield and selectivity are presented. Key-words. Supercritical CO2, Friedel-Crafts acylation, zeolite

Item Type:Conference or Workshop Item (Speech)
Audience (conference):International conference proceedings
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
Laboratory name:
Laboratoire de Génie Chimique - LGC (Toulouse, France) - Réaction, mélange & séparation (RMS)
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Deposited By:Guylène Abadie

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