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Nanocrystalline apatites in biological systems: characterisation, structure and properties

Rey, Christian and Combes, Christèle and Drouet, Christophe and Lebugle, Albert and Sfihi, Hocine and Barroug, Allal Nanocrystalline apatites in biological systems: characterisation, structure and properties. (2007) Materialwissenschaft und Werkstofftechnik, vol. 38 (n° 12). pp. 996-1002. ISSN 0933-5137

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Official URL: http://dx.doi.org/10.1002/mawe.200700229

Abstract

Nanocrystalline apatitic calcium phosphates play a crucial role in calcified tissues and biomaterials. One of the most interesting characteristics of biomimetic apatite nanocrystals is the existence of a surface hydrated layer essentially related to their formation process in solution. This hydrated layer shows specific spectroscopic characteristics. It seems to exist in its nascent state only in wet samples and is altered on drying. This surface-hydrated layer progressively disappears as the stable apatite domains develop. The surface ions can be rapidly and reversibly exchanged in solution, mainly with selected bivalent species. The exchange reactions clearly reveal the existence of two domains: the relatively inert apatite core and the very reactive surface-hydrated domains. The structure of the hydrated layer has been shown to be reversibly affected by the constituting ions. Such a surface layer in bone apatite nanocrystals could participate actively in homeostasis and probably other regulation processes. The specificity of biomimetic apatite nanocrystals also opens interesting possibilities in materials science. The mobility of the mineral ions on the crystal surface, for example, allows strong bonding and interactions either with other crystals or with different substrates. Inter-crystalline interactions have been described as a “crystal fusion” process in vivo and they could be involved in the setting reaction of biomimetic calcium phosphate cements. Ceramic-like materials using the surface interaction capabilities of the nanocrystals can be produced at very low temperature (below 200 C). The surface-hydrated layer could also be involved in interactions with macromolecules and polymeric materials or in the coating of implants. The ion exchange and adsorption capabilities of the nanocrystals could probably be used for drug release, offering a range of possible behaviours.

Item Type:Article
Additional Information:Thanks to John Wiley & Sons editor. The definitive version is available at http://www3.interscience.wiley.com The original PDF of the article can be found at Materialwissenschaft und Werkstofftechnik website : http://www3.interscience.wiley.com/journal/60500231/home
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:Other partners > Ecole Supérieure de Physique et de Chimie Industrielles - ESPCI (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Other partners > University of Cadi Ayyad - UCAM (MOROCCO)
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
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Deposited By:Celine Cabaup

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