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Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice

Parnaud, Géraldine and Taché, Sylviane and Peiffer, Ginette and Corpet, Denis E. Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice. (2001) British Journal of Cancer, vol. 8 (n° 1). pp. 90-93. ISSN 0007-0920

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Official URL: http://www.nature.com/bjc/journal/v84/n1/pdf/6691540a.pdf

Abstract

Polyethylene-glycol (PEG) is a strong inhibitor of colon cancer in rats, and the most potent suppressor of aberrant crypt foci. Nine PEG-like block copolymers were tested in rodents, after an azoxymethane injection. Dietary pluronic F68 led to a 98.6% reduction in the number of aberrant crypt foci in a first rat study (P < 0.0001). Next 3 studies confirmed this pluronic efficacy in rats and mice. This non-toxic laxative seems roughly five times more potent than PEG for chemoprevention.

Item Type:Article
Additional Information:Thanks to Nature Publishing Group. The original PDF of the article can be found at the British Journal of Cancer website : http://www.nature.com/bjc
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Institut National de la Recherche Agronomique - INRA
Other partners > National Cancer Institute (USA)
Université de Toulouse > Ecole Nationale Vétérinaire de Toulouse - ENVT
Laboratory name:
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Deposited By:Denis CORPET

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