Lacan, Jérôme and Michel, Christian Analysis of a circular code model. (2001) Journal of Theoretical Biology, vol. 2 (n° 2). pp. 159-170. ISSN 0022-5193
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Official URL: http://dx.doi.org/10.1006/jtbi.2001.2416
A circular code has been identified in the protein (coding) genes of both eukaryotes and prokaryotes by using a statistical method called Trinucleotide Frequency method (TF method) [Arquès & Michel, (1996) J.Theor. Biol. 182, 45-58]. Recently, a probabilistic model based on the nucleotide frequencies with a hypothesis of absence of correlation between successive bases on a DNA strand, has been proposed by Koch & Lehmann [(1997) J.Theor. Biol. 189, 171-174] for constructing some particular circular codes. Their interesting method which we call here Nucleotide Frequency method (NF method), reveals several limits for constructing the circular code observed with protein genes.
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