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The biocompatibility of titanium in a buffer solution: compared effects of a thin film of TiO2 deposited by MOCVD and of collagen deposited from a gel

Popescu, Simona and Demetrescu, Ioana and Sarantopoulos, Christos and Gleizes, Alain and Iordachescu, Dana The biocompatibility of titanium in a buffer solution: compared effects of a thin film of TiO2 deposited by MOCVD and of collagen deposited from a gel. (2007) Journal of Materials Science: Materials in Medicine, vol. 18 (n° 10). pp. 2075-2083. ISSN 0957-4530

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Official URL: http://dx.doi.org/10.1007/s10856-007-3133-3

Abstract

This study aims at evaluating the biocompatibility of titanium surfaces modified according two different ways: (i) deposition of a bio-inert, thin film of rutile TiO2 by chemical vapour deposition (MOCVD), and (ii) biochemical treatment with collagen gel, in order to obtain a bio-interactive coating. Behind the comparison is the idea that either the bio-inert or the bio-active coating has specific advantages when applied to implant treatment, such as the low price of the collagen treatment for instance. The stability in buffer solution was evaluated by open circuit potential (OCP) for medium time and cyclic voltametry. The OCP stabilized after 5104 min for all the specimens except the collagen treated sample which presented a stable OCP from the first minutes. MOCVD treated samples stabilized to more electropositive values. Numeric results were statistically analysed to obtain the regression equations for long time predictable evolution. The corrosion parameters determined from cyclic curves revealed that the MOCVD treatment is an efficient way to improve corrosion resistance. Human dermal fibroblasts were selected for cell culture tests, taking into account that these cells are present in all bio-interfaces, being the main cellular type of connective tissue. The cells grew on either type of surface without phenotype modification. From the reduction of yellow, water-soluble 3-(4,5-dimethyldiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT cytotoxicity test), MOCVD treated samples offer better viability than mechanically polished Ti and collagen treated samples as well. Cell spreading, as evaluated from microscope images processed by the program Sigma Scan, showed also enhancement upon surface modification. Depending on the experimental conditions, MOCVD deposited TiO2 exhibits different nanostructures that may influence biological behaviour. The results demonstrate the capacity of integration in simulated physiologic liquids for an implant pretreated by either method.

Item Type:Article
Additional Information:Thanks to Springer Verlag editor. The definitive version is available at http://www.springerlink.com The original PDF of the article can be found at Journal of Materials Science: Materials in Medicine website : http://www.springerlink.com/content/100192/?p=767c6f6f00864c8886059fb651b5827a&pi=0
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Other partners > University of Bucharest (ROMANIA)
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
Other partners > University Politechnica of Bucharest (ROMANIA)
French research institutions > Centre National de la Recherche Scientifique - CNRS
Laboratory name:
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Deposited By:Celine Cabaup

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