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Thermal Reduction of Graphene Oxide Mitigates Its In Vivo Genotoxicity Toward Xenopus laevis Tadpoles

Evariste, Lauris and Lagier, Laura and Gonzalez, Patrice and Mottier, Antoine and Mouchet, Florence and Cadarsi, Stéphanie and Lonchambon, Pierre and Guillemine, Daffe and Chimowa, George and Sarrieu, Cyril and Ompraret, Elise and Galibert, Anne-Marie and Ghimbeu, Camelia and Pinelli, Eric and Flahaut, Emmanuel and Gauthier, Laury Thermal Reduction of Graphene Oxide Mitigates Its In Vivo Genotoxicity Toward Xenopus laevis Tadpoles. (2019) Nanomaterials, 9 (584). 1-16. ISSN 2079-4991

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Official URL: https://doi.org/10.3390/nano9040584

Abstract

The worldwide increase of graphene family materials raises the question of the potential consequences resulting from their release in the environment and future consequences on ecosystem health, especially in the aquatic environment in which they are likely to accumulate. Thus, there is a need to evaluate the biological and ecological risk but also to find innovative solutions leading to the production of safer materials. This work focuses on the evaluation of functional group-safety relationships regarding to graphene oxide (GO) in vivo genotoxic potential toward X. laevis tadpoles. For this purpose, thermal treatments in H2 atmosphere were applied to produce reduced graphene oxide (rGOs) with different surface group compositions. Analysis performed indicated that GO induced disturbances in erythrocyte cell cycle leading to accumulation of cells in G0/G1 phase. Significant genotoxicity due to oxidative stress was observed in larvae exposed to low GO concentration (0.1 mg.L−1). Reduction of GO at 200 °C and 1000 °C produced a material that was no longer genotoxic at low concentrations. X-ray photoelectron spectroscopy (XPS) analysis indicated that epoxide groups may constitute a good candidate to explain the genotoxic potential of the most oxidized form of the material. Thermal reduction of GO may constitute an appropriate “safer-by-design” strategy for the development of a safer material for environment.

Item Type:Article
HAL Id:hal-02095596
Audience (journal):Special issue journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
French research institutions > Institut national de Recherche en Sciences et Technologies pour l'Environnement et l'Agriculture - IRSTEA (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > Université de Bordeaux (FRANCE)
Other partners > Université de Haute Alsace - UHA (FRANCE)
Laboratory name:
Funders:
CNRS
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Deposited By: florence mouchet
Deposited On:10 Apr 2019 13:26

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