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Relationships between density and Young’s modulus with microporosity and physico-chemical properties of Wistar rat cortical bone from growth to senescence

Vanleene, M. and Rey, Christian and Ho Ba Tho, Marie-Christine Relationships between density and Young’s modulus with microporosity and physico-chemical properties of Wistar rat cortical bone from growth to senescence. (2008) Medical Engineering and Physics, vol. 30 (n° 8). pp. 1049-1056. ISSN 1350-4533

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Official URL: http://dx.doi.org/10.1016/j.medengphy.2007.12.010

Abstract

The aim of this study is to assess density and elastic properties of Wistar rat cortical bone from growth to senescence and to correlate them with morphological and physico-chemical properties of bone. During growth (from 1 to 9 months), bone density and Young’s modulus were found to increase from 1659±85 to 2083±13 kg m−3 and from 8±0.8 to 19.6±0.7 GPa respectively. Bone microporosity was found to decrease from 8.1±0.7% to 3.3±0.7%. Physico-chemical investigations exhibited a mineralization of bone matrix and a maturation of apatite crystals, as protein content decreased from 21.4±0.2% to 17.6±0.6% and apatite crystal size and carbonate content increased (c-axis length: from 151 to 173 Å and CO3W%: from 4.1±0.3% to 6.1±0.2%). At adult age, all properties stabilized. During senescence, a slow decrease of mechanical properties was first observed (from 12 to 18 months, ρ=2089±14 to 2042±30 kg m−3 and E3=19.8 ±1.3 to 14.8±1.5 GPa), followed by a stabilization. Physico-chemical properties stabilized while microporosity increased slightly (from 3.3% to 4%) but not significantly (p>0.05). A multiple regression analysis showed that morphological and physico-chemical properties had significant effects on density regression model. Microporosity had a greater effect on Young’s modulus regression model than physico-chemical properties. This study showed that bone structure, mineralization and apatite maturation should be considered to improve the understanding of bone mechanical behaviour.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Medical Engineering and Physics website : http://www.sciencedirect.com/science/journal/13504533
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
Other partners > Université de Technologie de Compiègne – UTC (FRANCE)
Laboratory name:
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Deposited By:Celine Cabaup

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