OATAO - Open Archive Toulouse Archive Ouverte Open Access Week

Surface enrichment of biomimetic apatites with biologically-active ions Mg2+ and Sr2+: A preamble to the activation of bone repair materials

Drouet, Christophe and Carayon, Marie-Thérèse and Combes, Christèle and Rey, Christian Surface enrichment of biomimetic apatites with biologically-active ions Mg2+ and Sr2+: A preamble to the activation of bone repair materials. (2008) Materials Science and Engineering C, vol. 28 (n° 8). pp. 1544-1550. ISSN 0928-4931

[img]
Preview
(Document in English)

PDF (Author's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
670kB

Official URL: http://dx.doi.org/10.1016/j.msec.2008.04.011

Abstract

The surface activation of calcium phosphate-based biomaterials for bone repair is an emerging route for improving bone regeneration processes. One way for such activation is through the exchange of surface calcium ions with biologically-active cations such as Mg2+ or Sr2+. In this work, the interactions of noncarbonated and carbonated nanocrystalline apatites with Mg2+ and Sr2+ were investigated by means of ion exchange experiments in solution. Langmuir-type isotherms were determined. For both Sr and Mg, a greater uptake was observed on the carbonated sample, and on both types of apatites the maximum strontium uptake was greater than that of magnesium. Inverse exchanges showed that the proportion of reversibly fixed ions after surface exchange was close to 85% for Mg and 75–80% for Sr. The results are related to the presence of a surface hydrated layer on the nanocrystals and possible exchange mechanisms are discussed. Our results favor the hypothesis of hetero-ionic surface exchanges (Mg2+↔Ca2+, Sr2+↔Ca2+) within the hydrated layer, and some analogy with octacalcium phosphate (OCP) is considered. This work should prove helpful for the control and understanding of the activation of synthetic apatite-based powders or scaffolds with bioactive elements, as well as for the global understanding of biomineralization processes.

Item Type:Article
Additional Information:Thanks to Elsevier editor. The definitive version is available at http://www.sciencedirect.com The original PDF of the article can be found at Materials Science and Engineering C website : http://www.sciencedirect.com/science/journal/09284931
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution: Université de Toulouse > Institut National Polytechnique de Toulouse - INPT
Université de Toulouse > Université Paul Sabatier-Toulouse III - UPS
French research institutions > Centre National de la Recherche Scientifique - CNRS
Laboratory name:
Statistics:download
Deposited By: Celine Cabaup
Deposited On:20 Apr 2009 12:28

Repository Staff Only: item control page