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Phenolic composition and prospective anti-infectious properties of Atriplex lindleyi

Souda, Sahar Salah El Din El and Matloub, Azza Abdelmageed and Nepveu, Françoise and Valentin, Alexis and Roques, Christine Phenolic composition and prospective anti-infectious properties of Atriplex lindleyi. (2015) Asian Pacific Journal of Tropical Disease, 5 (10). 786-791. ISSN 2222-1808

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Official URL: https://doi.org/10.1016/S2222-1808(15)60931-8

Abstract

Objective: To investigate the antiplasmodial, antimicrobial, radical scavenging effects and to identifiy the phenolic constituents of Atriplex lindleyi (A. lindleyi). Methods: A. lindleyi extracts and some isolated compounds were tested in vitro against the chloroquine-resistant strains of lasmodium falciparum. The radical scavenging activity was quantified by using 2,2-diphenyl-2-picrylhydrazyl nitrogen-centered free radical. The IC50 of each extract was compared with references. The in vitro anti-infectious activity of extracts was evaluated against representative Gram-positive and Gram-negative bacterial strains [Staphylococcus aureus CIP 4.83, Enterococcus hirae CIP 5855, Pseudomonas aeruginosa (P. aeruginosa) CIP 82118, Escherichia coli CIP 53126], and fungal species [(Candida albicans (C. albicans) IP 48.72, Aspergillus niger IP 1431.83]. Ethanol extract was investigated for chemical composition through column and high performance liquid chromatography. The isolated compounds were identified by mass spectrometry and nuclear magnetic resonance. Results: Quercetin-7-O-arabinopyranoside-3-O-neohesperidosides (1), quercetin-3-O-arabinopyranosyl(1→6) glucopyranoside (2), quercetin-3-O-glucopyranoside-7-O-rhamnopyranoside (3), quercetin-3-O-glucopyranoside-7-O-arabinoside (4), schaftoside (5), quercetin-7-O-glucopyranoside (6) were isolated for the first time from the ethanol extract of A. lindleyi aerial parts in addition to isorhamnetin-3-O-β-glucopyranoside (7) and quercetin (8). The extracts exhibited moderate antiplasmodial activity with IC50≈ranging from 10–50 µg/mL. Quercetin was the most potent compound with IC50 of 9 µg/mL. P. aeruginosa and C. albicans were the most susceptible organisms. Conclusions: The study implies that A. lindelyi can contribute to the fight against malaria, and be useful as prophylactic against C. albicans and P. aeruginosa.

Item Type:Article
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Other partners > National Research Center - NRC (Egypt)
Laboratory name:
Funders:
European Commission
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Deposited By: Loetitia MOYA
Deposited On:01 Mar 2019 10:04

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