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Unmixing dynamic PET images with variable specific binding kinetics

Cruz Cavalcanti, Yanna and Oberlin, Thomas and Dobigeon, Nicolas and Stute, Simon and Ribeiro, Maria and Tauber, Clovis Unmixing dynamic PET images with variable specific binding kinetics. (2018) Medical Image Analysis, 49. 117-127. ISSN 1361-8415

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Official URL: https://doi.org/10.1016/j.media.2018.07.011

Abstract

To analyze dynamic positron emission tomography (PET) images, various generic multivariate data analysis techniques have been considered in the literature, such as principal component analysis (PCA), independent component analysis (ICA), factor analysis and nonnegative matrix factorization (NMF). Nevertheless, these conventional approaches neglect any possible nonlinear variations in the time activity curves describing the kinetic behavior of tissues with specific binding, which limits their ability to recover a reliable, understandable and interpretable description of the data. This paper proposes an alternative analysis paradigm that accounts for spatial fluctuations in the exchange rate of the tracer between a free compartment and a specifically bound ligand compartment. The method relies on the concept of linear unmixing, usually applied on the hyperspectral domain, which combines NMF with a sum-to-one constraint that ensures an exhaustive description of the mixtures. The spatial variability of the signature corresponding to the specific binding tissue is explicitly modeled through a perturbed component. The performance of the method is assessed on both synthetic and real data and is shown to compete favorably when compared to other conventional analysis methods.

Item Type:Article
Additional Information:https://www.sciencedirect.com/science/article/pii/S1361841518305541
Audience (journal):International peer-reviewed journal
Uncontrolled Keywords:
Institution:French research institutions > Commissariat à l'Energie Atomique et aux énergies alternatives - CEA (FRANCE)
French research institutions > Centre National de la Recherche Scientifique - CNRS (FRANCE)
Université de Toulouse > Institut National Polytechnique de Toulouse - INPT (FRANCE)
French research institutions > Institut National de la Santé et de la Recherche Médicale - INSERM (FRANCE)
Université de Toulouse > Université Toulouse III - Paul Sabatier - UPS (FRANCE)
Université de Toulouse > Université Toulouse - Jean Jaurès - UT2J (FRANCE)
Université de Toulouse > Université Toulouse 1 Capitole - UT1 (FRANCE)
Other partners > Université François-Rabelais de Tours (FRANCE)
Other partners > Université Paris-Sud 11 (FRANCE)
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Deposited By: IRIT IRIT
Deposited On:18 Jun 2019 14:53

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